Endoret® PRGF®

Product Description:

Endoret® (PRGF®) is a platelet-rich plasma (PRP) technology for obtaining autologous proteins from the patient’s own blood.

BTI Biotechnology Institute

BTI is considered a worldwide scientific reference in regenerative medicine. This recognition is the result of the successful use of Endoret® (PRGF®) in different medical specialties such as dentistry, traumatology, dermatology, ophthalmology, sports medicine, vascular surgery, aesthetics, among others.

Endoret® PRGF® is a closed system, with the necessary equipment and unitary and disposable kits certified for such use that allows a rapid preparation of plasma under sterile conditions and its immediate application.

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Regenerative Medicine Plasma Rich with Growth Factors

Articles & Media

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Progress in the use of plasma rich in growth factors in ophthalmology: from ocular surface to ocular fundus.

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Plasma rich in growth factors (PRGF) eye drops stimulates scarless regeneration compared to autologous serum in the ocular surface stromal fibroblasts.

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Corneal wound healing promoted by 3 blood derivatives: an in vitro and in vivo comparative study.

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Safety and Efficacy of Autologous Plasma Rich in Growth Factors Eye Drops for the Treatment of Evaporative Dry Eye.

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Treatment of patients with neurotrophic keratitis stages 2 and 3 with plasma rich in growth factors (PRGF-Endoret) eye-drops.

Advantages of PRGF®

Autologous and rich in Growth Factors

Taken from patient’s blood, so there is less possibility of side effects
It promotes homeostasis
Stimulates cell proliferation and migration
It stimulates the endogenous secretion of proteins from the extracellular matrix

Optimal concentration of Growth Factors

Platelet concentration compared to baseline between 2 and 3 times
Balance between growth factors:
- Platelet-based (released by platelets)
- Plasma-based (present free in plasma)

Free from leukocytes and inflammatory proteins

Process includes elimination of leukocytes, Complement C and IgE
Preserves the integrity of the fibrin matrix over time

Controlled activation

Promotes the release of growth factors from platelet
Induces polymerisation of the fibrin matrix

Scientific evidence

Technology endorsed by more than 200 indexed scientific publications

Endoret® PRGF®: Closed Technique

What is the difference between the closed and the open technique?

Closed technique:
- Utilizes disposable, single-use kits; the instructions given by the manufacturer of each system must be followed without it being necessary to obtain a certificate of adequacy from the facilities.
Open technique:
- The method for obtaining PRP should be evaluated and authorised by an inspection by the competent health regulation to verify the suitability of the facilities and the production activities.

How do I prescribe Endoret® (PRGF®) to my patients?

Labtician has created the ECP Network for you to easily book Endoret® (PRGF®) treatments for your patients. And we have partnered with BioScript Solutions to provide patient access to Endoret® (PRGF®) to a number of its Coverdale Infusion Clinics located across Canada.

Patient Video

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SIMPLIFYING ACCESS TO Endoret® (PRGF®)

Labtician has created the ECP Network for you to easily book Endoret® (PRGF®) treatments for your patients.

Connect with your local Labtician representative to be enrolled on the ECP Network and begin providing Endoret® (PRGF®) to your patients.

Labtician has partnered with BioScript Solutions to provide patient access to Endoret® (PRGF®) at a number of its Coverdale Infusion Clinics located across Canada.

Once registered on the ECP Network, you will have access to available appointments at the local Coverdale Infusion Clinic(s) providing Endoret® (PRGF®) treatments in your province. The ECP Network will email your patients the necessary information, resources and reminders they can access regarding their Endoret treatment.

Coverdale Clinics provide patients with a safe, comfortable environment to receive specialty medications by infusion or injection. The highly experienced nurses who run the Coverdale Clinics will go above and beyond to ensure your patients are comfortable and that their Endoret® (PRGF®) experience is as seamless as possible.

They take a personalized approach to patient care that includes education and counselling to better support Endoret® (PRGF®) adherence and help achieve the best outcomes possible.

References – Click Here for the Literature Review

Anitua E, de la Sen-Corcuera B, Orive G, Sánchez-Ávila RM, Heredia P, Muruzabal F, Merayo-Lloves J. Progress in the use of plasma rich in growth factors in ophthalmology: from ocular surface to ocular fundus. Expert Opin Biol Ther. 2021 Jul 19:1-15. doi: 10.1080/14712598.2021.1945030.

Anitua E, de la Fuente M, Muruzabal F, Riestra A, Merayo-Lloves J, Orive G. Plasma rich in growth factors (PRGF) eye drops stimulates scarless regeneration compared to autologous serum in the ocular surface stromal fibroblasts. Exp Eye Res. 2015 Jun;135:118-26. doi: 10.1016/j.exer.2015.02.016.

Freire V, Andollo N, Etxebarria J, Hernáez-Moya R, Durán JA, Morales MC. Corneal wound healing promoted by 3 blood derivatives: an in vitro and in vivo comparative study. Cornea. 2014 Jun;33(6):614-20. doi: 10.1097/ICO.0000000000000109.

Merayo-Lloves J, Sanchez-Avila RM, Riestra AC, et al. Safety and Efficacy of Autologous Plasma Rich in Growth Factors Eye Drops for the Treatment of Evaporative Dry Eye. Ophthalmic Res. 2016;56(2):68-73. doi:10.1159/000444496

Sanchez-Avila RM, Merayo-Lloves J, Riestra AC, et al. Treatment of patients with neurotrophic keratitis stages 2 and 3 with plasma rich in growth factors (PRGF-Endoret) eye-drops. Int Ophthalmol. 2018;38(3):1193-1204. doi:10.1007/s10792-017-0582-7